At Enantis, we understand the profound impact that growth factors (GFs) have on skin health and aging. GFs are proteins, also known as polypeptides, that bind to cell surface receptors and directly influence target cells through cellular proliferation and differentiation. Among these, Fibroblast Growth Factors (FGFs) are particularly noteworthy for their significant roles in various tissues, including the skin, brain, nervous system, eyes, blood vessels, heart, stomach, liver, kidneys, muscles, and bones. We develop stable FGFs as novel therapeuticals for medicine and as new revolutionary cosmetic ingredients.

The Importance of Fibroblast Growth Factors (FGFs) in the context of polypeptides used in skin care cosmetics

FGFs are vital for maintaining and rejuvenating tissues. They interact with specific cell-surface receptors, influencing a wide array of biological processes essential for optimal skin function, such as collagen and elastin maturation, fibroblast migration, and retaining skin hydration. However, the challenge with traditional polypeptides is their instability; they can be easily denatured by heat, acid, or enzymatic activity during the production and distribution chain, limiting their effectiveness in topical applications. Ultimately, customers often buy products with inactive and “dead” FGF polypeptides.

Introducing heat stable FGF2-STAB: A Breakthrough in Anti-Aging by Enantis

At Enantis, we have developed FGF2-STAB, a heat stable form of Fibroblast Growth Factor 2 (INCI: SH-POLYPEPTIDE-1), a specifical active molecule designed for use in anti-aging cosmetics. Our innovative formulation addresses the instability issues associated with traditional FGFs, ensuring that the polypeptide remains effective when applied topically. FGF2-STAB is a reliable solution for skin rejuvenation, offering numerous benefits for anti-aging treatments. FGF2-STAB, with its superior heat stability, outperforms all growth factors in the cosmetic market.

Unique Anti-Aging Effects of FGF2-STAB polypeptide

Aging is characterized by cellular degeneration caused by oxidative stress and free radical damage. FGFs play a critical role in maintaining and repairing tissues with fibrous components, such as the skin, eyes, heart, brain, and musculoskeletal system. FGF2-STAB helps repair damaged tissue, rejuvenate aging skin, and promote healthier, younger-looking skin by enhancing cellular proliferation, collagen and elastin maturation, fibroblast migration, and retaining skin hydration.

Proven Benefits of heat stable FGF2-STAB in Anti-Aging Cosmetics

FGF2-STAB provides numerous benefits when used in anti-aging cosmetic products:

1. Skin Rejuvenation: FGF2-STAB promotes the repair and renewal of skin cells, helping to reduce wrinkles and improve skin elasticity, resulting in a more youthful appearance.
2. Tissue Repair: FGF2-STAB aids in repairing damaged tissues, such as injured nerve tissue and damaged blood vessels, preventing further complications and promoting overall skin health.
3. Enhanced Stability: Unlike traditional FGFs, heat stable FGF2-STAB is much more resistant to denaturation, ensuring that the active polypeptide remains effective and delivers consistent results.
4. Formulation Compatibility: FGF2-STAB can be added to creams, serums, and gels in very low concentrations to achieve the anti-aging effect of this bioactive polypeptide.
5. No Preservatives: FGF2-STAB does not contain any chemical stabilizers or preservatives. Thermal stability is improved by amino acid changes in the protein sequence.
6. Enhanced collagen maturation and elastin production: FGF2-STAB promotes sustained collagen maturation and increased elastin production by continuously stimulating fibroblasts. Its extended activity leads to improved extracellular matrix remodeling, enhancing tissue strength and elasticity.

Fibroblast Growth Factors, particularly our innovative FGF2-STAB polypeptide, represent a significant advancement in anti-aging cosmetics. At Enantis, we are proud to lead the way in developing stable, effective growth factors that are crucial for maintaining and enhancing the function of various organs and tissues. With its enhanced stability and targeted action, FGF2-STAB stands out as a groundbreaking ingredient, promising to deliver remarkable anti-aging benefits and transform skincare routines. Incorporating FGF2-STAB into cosmetic formulations ensures a reliable and effective approach to achieving healthier, younger-looking skin.

Choose Enantis and FGF2-STAB for your polypeptide-based skincare solutions and experience the future of anti-aging science today OR explore our e-shop!

🚀 Big news at Enantis! 🚀

We’re excited to welcome Marek Atanasčev as our new CEO, effective October 1, 2024. Marek succeeds Roman Badik, who led Enantis through incredible growth and innovation, including expanding globally and winning key industry awards.

With Marek’s international experience, we’re ready to take Enantis to the next level and continue pushing boundaries in biotechnology!

hashtag#LeadershipChange hashtag#Innovation hashtag#Biotechnology hashtag#Enantis hashtag#GlobalExpansion

At In-Cosmetics 2024 in Paris, we started an exciting collaboration with Sunfine Global (Juyeon Song), a Korean cosmetics and chemical ingredients company. Terézia Ikrényiová and Alzbeta Hauser are now set to present our groundbreaking anti-aging ingredient in Korea in a couple of days, aiming to attract customers in Korea and expand our market presence across the broader Asian market. Kamsahamnida (감사합니다) to Sunfine Global for this opportunity.

Enantis is humbled and beyond excited to win the BRKTHRU VOICES award by The Estée Lauder Companies Inc. Out of over a hundred innovative companies, Enantis emerged victorious. This remarkable recognition propels us forward, empowering us to forge vital connections within the cosmetics industry and propel our groundbreaking FGF2-STAB product into the market.

This win comes as an unexpected yet immensely welcome validation of our efforts, especially considering we have just launched our first cosmetics product. It signifies not only our dedication to innovation (drum roll for Terézia Ikrényiová, MSc. and Jan Herudek in our cosmetics team) but also the industry’s recognition of our potential to drive transformative change.

It has been nice to meet the other finalists and we hope there will be a chance to collaborate further – AM BioTech – Ascension Medical Biotechnology, Oriel Marine Extracts, SETHIC INNOVATIONS and SupadElixir.

Thank you to The Estée Lauder Companies Inc. and in-cosmetics Global for this incredible honor. This award fuels our determination to continue pushing boundaries and making a lasting difference in the cosmetics industry. 🚀

We’re thrilled to announce that Enantis will be participating at InCosmetics 2024 in Paris, 16-18th April! 🇫🇷
Join us at Booth 1A35 as we unveil our latest innovation: the FGF2-STAB® product for cosmetics use.
Our team has been hard at work developing this groundbreaking product, leveraging the power of FGF2 to revolutionize the cosmetics industry. With its unparalleled benefits, FGF2-STAB® promises to redefine skincare and beauty standards.
Don’t miss this opportunity to experience the future of cosmetics firsthand!
Visit us at InCosmetics 2024 to learn more about FGF2-STAB® and discover how it can elevate your cosmetics products.

See you there!

Exciting News from Enantis!
Our brilliant PhD candidate, Gabin de La Bourdonnaye, has developed a game-changing thermostable FGF21 growth factor 🌡️, soon to join Enantis’ portfolio. Check out the paper here: https://lnkd.in/eFfzBBT8

This novel growth factor has the potential to revolutionize metabolic disease treatment— think obesity, dyslipidemia, and insulin intolerance. Engineered for thermostability, it shows improved pharmacokinetics, allowing for lower dosage and reduced administration frequency, minimizing side effects.

Interested in exploring the potential of thermostable FGF21? Reach out, and we’ll provide more info.

Let’s shape the future of growth factors together! 🚀

We are thrilled to share that our FGF2-STAB® has been granted a patent in India! 🇮🇳
As we celebrate, we’re also expanding our patent portfolio to cover more territories. Stay tuned for more innovations!

🎉 Fantastic News! 🎉
Enantis has just been granted a US patent for its groundbreaking invention of FGF2-STAB®. This engineered protein is a true game-changer – it’s a thermostable powerhouse 🌡️🔥, boasting a mind-boggling stability that’s 50-times greater at 37°C than that of wild type FGF2. 💪
This opens up a world of possibilities in the realm of biotechnology, with potential applications that can revolutionize research, therapies, cosmetics, cultured meat and beyond. 🌐🔬
A huge round of applause to our brilliant team and also to Masaryk University team for pushing the boundaries of what’s possible in science and biotech! 🧬

#patentgranted #USpatent #brnoregion #IP

💡Join us once again as we unveil the next chapter in our “Meet Enantis” series with issue nine!💡

Our plan is to introduce all the brilliant minds that fuel Enantis’ innovation, as our company is not just about business – it’s about the people who make the magic happen!

This time, we’re thrilled to introduce Jan Vilím, our Head of Production and R&D 🧪🧬, and offer you an insightful interview that gives a glimpse into his role and experiences at Enantis. Delve into the world of production and research as Jan shares his journey, thoughts, and passions.

Meet Enantis series is a unique opportunity to get to know the people who drive Enantis’ innovation on a personal level. Stay tuned for more candid conversations that shed light on the inner workings of our company and the individuals who contribute to its success.

INTERVIEW HERE

#biotech #production #HR #randd #brnoregion

FGF2-STAB®: Clinically Proven Cosmetics Ingredient!

Enantis is thrilled to share some amazing news with you! FGF2-STAB®, a groundbreaking cosmetics ingredient, has been clinically and dermatologically tested and proven effective. It was shown that it retains skin hydration, reduces wrinkles, and softens the skin.

FGF2-STAB® underwent rigorous testing, showing impressive results. Participants experienced improved skin hydration leading to visible wrinkle reduction and softer skin. What’s more, FGF2-STAB® is safe to use, with no cytotoxicity or skin irritation observed during testing.

This verification of FGF2-STAB® as an effective cosmetics ingredient is a game-changer in achieving optimal skin health. This revolutionary product is now available for supply and licensing as an innovative cosmetics ingredient. We will be happy to hear from you if you want to give it a try in your cosmetics formulation.

Exciting times ahead!