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Thermostable FGF10 developed and manufactured by Enantis (patent application WO2023089157A1)
Stabilized fibroblast growth factor 10 is a revolutionary hair growth-promoting ingredient that solves the instability of growth factors in cosmetics
- Enhances hair follicle activity
- Elongates anagen phase of hair cycle
- Activates keratinocytes
- Reduces microinflammation that causes hair loss
- No stabilizing additives
- Cost-effective
COMPETITIVE ADVANTAGE
Native growth factors suffer from low stability limiting their utilization in cosmetics during production, transport and application. FGF10-STAB® outperforms native forms of growth factors due to its significantly improved stability
FGF10-STAB® vs. FGF10
| FGF10 | FGF10-STAB® | FGF10-STAB® BENEFITS | |
| ACTIVITY AT 37°C | < 2 hours | > 24 hours | More stable during biological processes |
| HALF-LIFE AT 37 ˚C | <11 hours | >24 hours | More stable during biological processes |
| PROTEOLYSIS AT 37 ˚C | <10 minutes | >1 hour | More stable during biological processes |
| STABILITY AT 25°C | < 10 weeks | > 8 months | Stable for a longer period(transportation and storage) |
| STABILITY AT 40°C | < 1 week | 6 months | Stable for a longer period(transportation and storage) |
| ACTIVITY (ED50) | 0.8 ng/ml | 0.2 ng/ml | Lower concentration required(reduced costs) |
| MELTING TEMP. | 45 °C | 64 °C | Stable at higher temperature (heating during production) |
Higher stability of FGF10-STAB®
SPECIFICATIONS
| INCI | AQUA SODIUM CHLORIDE DIPOTASSIUM PHOSPHATE MONOPOTASSIUM PHOSPHATE SH-POLYPEPTIDE-10 |
| CAS NUMBER | 67254-75-5 |
| APPEARANCE | Colourless aqueous solution |
| BUFFER | 250 mM Sodium chloride, 16.4 mM Potassium hydrogen phosphate, 3.6 mM Potassium dihydrogen phosphate, pH 7.5 |
| pH | 7.5 |
| CONCENTRATION (RECOMMENDED) | 1–10 ppm (1–10 μg/ml) in the final formulation |
| USE | Hair tonics, serums, masks, and eyelash serums. |
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