Would you like to delve deeper into protein engineering?

Loschmidt Laboratories together with Enantis organize an interactive hands-on course exploring web-based tools suitable for mining new enzymes and engineering enzyme activity, specificity, enantioselectivity, stability, and solubility. To remain at the cutting edge of scientific advancements, we will also explore the applications of machine learning techniques and quantum computing in enzyme design.

You will have the chance to learn from the developers or experienced users of those tools and discuss the optimal ways to set-up calculations and adequately interpret the results. At the end of this 4-day course, you will be able to design different properties of proteins for your academic research or commercial applications on your own.

When: 2-5 June 2025

Where: Brno, Czech Republic (on-site)

Interested? Sign up here:

https://loschmidt.chemi.muni.cz/academy/

We still have free slots with an early-bird discount (till the end of March). Do not miss the opportunity and apply now! 

Discover the power of FGF2-STAB®, our innovative heat-stable fibroblast growth factor, now available for direct purchase in the Enantis e-shop. Designed for diverse and demanding applications, FGF2-STAB® ensures enhanced stability, reproducibility, and long-lasting activity.

At Enantis, we are proud to supply our heat-stable FGF2 to many of the world’s leading laboratory suppliers. Furthermore, we have licensed our heat-stable FGF technology to various companies, allowing them to market these groundbreaking products under their own brands.

Applications of heat stable FGF2-STAB®

1. Regenerative Medicine
   • FGF2-STAB® promotes cell proliferation and tissue regeneration, making it invaluable in stem cell therapies, wound healing, and organoid development.
2. Cosmetics
   • In skincare formulations, FGF2-STAB® enhances collagen production and cell renewal, delivering sustained and visible results for anti-aging products.
3. Cultivated Meat
   • As a critical component in growth media, FGF2-STAB® supports muscle cell growth and differentiation, reducing media costs and enhancing scalability for lab-grown meat production.
4. Tissue Engineering
   • With its unparalleled stability and activity, FGF2-STAB® is the ideal choice for creating engineered tissues used in research and therapeutic applications.
5. Biomedical Research
   • Researchers rely on FGF2-STAB® for studies involving cell signaling, tissue repair, and protein stability, benefiting from its reproducibility and robust performance.

Available Now on the Enantis E-Shop

Ready to elevate your research or product development? FGF2-STAB® is now available for purchase on the Enantis E-shop. With user-friendly access and detailed product descriptions, the e-shop simplifies the ordering process for scientists, researchers, and industry professionals alike.

Biotechnology pioneer Enantis is advancing the development of FGF10-STAB, a hyper-stable fibroblast growth factor, to provide innovative treatment solutions for patients with severe forms of Acute Respiratory Distress Syndrome (ARDS). ARDS is a life-threatening condition characterized by rapid onset of widespread inflammation in the lungs, often requiring mechanical ventilation. With a high mortality rate and no effective treatment available, there is an urgent need for new therapies that target the underlying causes and support recovery. 

FGF10-STAB stands out as a promising candidate due to its ability to promote tissue regeneration, reduce inflammation, and enhance alveolar repair. Its unique hyper-stable properties ensure prolonged activity and effectiveness, even under challenging conditions, making it an ideal candidate for addressing the needs of critically ill patients. The project focuses on determining the most effective delivery method—such as aerosol inhalation, endotracheal intubation, or carriers containing FGF10-STAB—and tailoring the solution for ventilated patients experiencing severe ARDS progression. 

Collaborating with members of the CZECRIN Pneumo platform, including doc. MUDr. Vladimír Koblížek, Ph.D. (FN Hradec Králové), prof. MUDr. Miloslav Marel, CSc. (FN Motol), MUDr. Petr Jakubec, Ph.D. (FN Olomouc), and MUDr. Ondřej Fibigr (FN Plzeň), Enantis is refining its approach by incorporating direct clinical feedback. These experts are providing essential guidance on formulating FGF10-STAB, identifying target patient groups, and designing experiments that demonstrate the solution’s efficacy convincingly. 

Initiated in November 2024 with its first meeting on November 26th, the project continues into 2025, with further consultations planned for Q1. The ultimate goal is to finalize a clinical formulation of FGF10-STAB and progress to First in Human clinical trials to validate its safety and efficacy. “ARDS is a devastating condition that leaves clinicians with few effective tools, and the urgency to innovate has never been greater,” said Marek Atanasčev, CEO of Enantis. “Our work on FGF10-STAB reflects our commitment to bridging groundbreaking research with real-world clinical needs. By collaborating with leading experts through the CZECRIN Pneumo platform, we aim to develop a therapy that can transform outcomes for ARDS patients and set a new standard of care.” 

This project underscores Enantis’ mission to combine scientific excellence with meaningful clinical applications. FGF10-STAB exemplifies the company’s dedication to addressing complex challenges in respiratory medicine and beyond.  

We’re Hiring!

Enantis is looking for a passionate and driven Cellular Biologist to join our innovative biotech team in Brno!

If you’re excited about pushing the boundaries of science and contributing to the development of cutting-edge biotech solutions, we’d love to hear from you.

Take a look at the advert HERE

The world of cosmetics is evolving rapidly, and peptides are at the forefront of this transformation. These powerful molecules are changing the way we approach skincare, offering solutions that are scientifically advanced and results-driven. To delve deeper into this exciting field, Enantis invites you to an exclusive webinar: Peptides Unveiled: Transforming the Future of Cosmetics.

This is your opportunity to discover how peptides like FGF2-STAB®, a hyper-stable fibroblast growth factor, are revolutionizing beauty formulations and reshaping the cosmetics industry.

What to Expect in the Webinar

This interactive session is crafted specifically for professionals in the cosmetics industry, from formulators and product developers to R&D teams. Here’s what you’ll take away:

1. Unlock the Power of FGF2-STAB®
   Learn how this cutting-edge growth factor enhances skin rejuvenation, combats signs of aging, and promotes healthy, radiant skin. Its hyper-stability ensures sustained bioactivity, making it a game-changer for skincare products.
2. The Science Behind Beautiful Skin
   Discover the role peptides play in boosting collagen production, accelerating cellular repair, and delivering long-lasting, visible results. Gain insights into the biological mechanisms that make peptides indispensable for modern skincare formulations.
3. Innovation for the Beauty Industry
   Explore how Enantis uses groundbreaking biotechnology to make high-performance peptides more effective, stable, and accessible. This session highlights how these advancements can empower your brand to create standout products in a competitive market.
4. What’s Next in Skincare
   Stay ahead of the curve by exploring future trends and opportunities in peptide-based beauty solutions. From anti-aging innovations to targeted treatments, the possibilities are endless.

Why You Should Attend

In today’s fast-paced cosmetics industry, staying informed about emerging technologies is crucial. This webinar is perfect for:

• Cosmetic formulators seeking to enhance their product offerings.
• Product developers aiming to incorporate cutting-edge ingredients into their lines.
• R&D teams looking to innovate and drive market trends.

By attending, you’ll gain actionable insights that can elevate your skincare formulations and position your brand as a leader in innovation.

Date: January 29th, 2025

Time: 4 PM CET

Join the Revolution and register for the webinar here Microsoft Virtual Events Powered by Teams

At Enantis, we believe in science-driven solutions that deliver real results. Our hyper-stable peptides, like FGF2-STAB®, represent the next generation of beauty innovations, combining efficacy with reliability.

We’re excited to announce a new partnership with the Faculty of Pharmacy at Masaryk University! This collaboration gives students from the bachelor’s program in “Cosmetic Products” the chance to gain hands-on experience through internships at Enantis.

“At Enantis, we’re passionate about supporting the next generation of professionals in cosmetics. This partnership lets students put their knowledge into practice while learning about cutting-edge biotech approaches,” said Marek Atanasčev, CEO of Enantis.

By working with us, students will get an inside look at how innovative cosmetic ingredients and technologies are developed, helping them connect their academic studies with real-world applications. This partnership is a step forward in bridging the gap between education and industry while nurturing fresh talent in the field.

The Faculty of Pharmacy is just as excited and believes this collaboration will give their students valuable experience and a solid foundation for their careers.

We can’t wait to welcome these students to Enantis, where their ideas and energy will not only help them grow but will also contribute to the future of the biotechnology research and cosmetics industry!

At Enantis, we understand the profound impact that growth factors (GFs) have on skin health and aging. GFs are proteins, also known as polypeptides, that bind to cell surface receptors and directly influence target cells through cellular proliferation and differentiation. Among these, Fibroblast Growth Factors (FGFs) are particularly noteworthy for their significant roles in various tissues, including the skin, brain, nervous system, eyes, blood vessels, heart, stomach, liver, kidneys, muscles, and bones. We develop stable FGFs as novel therapeuticals for medicine and as new revolutionary cosmetic ingredients.

The Importance of Fibroblast Growth Factors (FGFs) in the context of polypeptides used in skin care cosmetics

FGFs are vital for maintaining and rejuvenating tissues. They interact with specific cell-surface receptors, influencing a wide array of biological processes essential for optimal skin function, such as collagen and elastin maturation, fibroblast migration, and retaining skin hydration. However, the challenge with traditional polypeptides is their instability; they can be easily denatured by heat, acid, or enzymatic activity during the production and distribution chain, limiting their effectiveness in topical applications. Ultimately, customers often buy products with inactive and “dead” FGF polypeptides.

Introducing heat stable FGF2-STAB: A Breakthrough in Anti-Aging by Enantis

At Enantis, we have developed FGF2-STAB, a heat stable form of Fibroblast Growth Factor 2 (INCI: SH-POLYPEPTIDE-1), a specifical active molecule designed for use in anti-aging cosmetics. Our innovative formulation addresses the instability issues associated with traditional FGFs, ensuring that the polypeptide remains effective when applied topically. FGF2-STAB is a reliable solution for skin rejuvenation, offering numerous benefits for anti-aging treatments. FGF2-STAB, with its superior heat stability, outperforms all growth factors in the cosmetic market.

Unique Anti-Aging Effects of FGF2-STAB polypeptide

Aging is characterized by cellular degeneration caused by oxidative stress and free radical damage. FGFs play a critical role in maintaining and repairing tissues with fibrous components, such as the skin, eyes, heart, brain, and musculoskeletal system. FGF2-STAB helps repair damaged tissue, rejuvenate aging skin, and promote healthier, younger-looking skin by enhancing cellular proliferation, collagen and elastin maturation, fibroblast migration, and retaining skin hydration.

Proven Benefits of heat stable FGF2-STAB in Anti-Aging Cosmetics

FGF2-STAB provides numerous benefits when used in anti-aging cosmetic products:

1. Skin Rejuvenation: FGF2-STAB promotes the repair and renewal of skin cells, helping to reduce wrinkles and improve skin elasticity, resulting in a more youthful appearance.
2. Tissue Repair: FGF2-STAB aids in repairing damaged tissues, such as injured nerve tissue and damaged blood vessels, preventing further complications and promoting overall skin health.
3. Enhanced Stability: Unlike traditional FGFs, heat stable FGF2-STAB is much more resistant to denaturation, ensuring that the active polypeptide remains effective and delivers consistent results.
4. Formulation Compatibility: FGF2-STAB can be added to creams, serums, and gels in very low concentrations to achieve the anti-aging effect of this bioactive polypeptide.
5. No Preservatives: FGF2-STAB does not contain any chemical stabilizers or preservatives. Thermal stability is improved by amino acid changes in the protein sequence.
6. Enhanced collagen maturation and elastin production: FGF2-STAB promotes sustained collagen maturation and increased elastin production by continuously stimulating fibroblasts. Its extended activity leads to improved extracellular matrix remodeling, enhancing tissue strength and elasticity.

Fibroblast Growth Factors, particularly our innovative FGF2-STAB polypeptide, represent a significant advancement in anti-aging cosmetics. At Enantis, we are proud to lead the way in developing stable, effective growth factors that are crucial for maintaining and enhancing the function of various organs and tissues. With its enhanced stability and targeted action, FGF2-STAB stands out as a groundbreaking ingredient, promising to deliver remarkable anti-aging benefits and transform skincare routines. Incorporating FGF2-STAB into cosmetic formulations ensures a reliable and effective approach to achieving healthier, younger-looking skin.

Choose Enantis and FGF2-STAB for your polypeptide-based skincare solutions and experience the future of anti-aging science today OR explore our e-shop!

🚀 Big news at Enantis! 🚀

We’re excited to welcome Marek Atanasčev as our new CEO, effective October 1, 2024. Marek succeeds Roman Badik, who led Enantis through incredible growth and innovation, including expanding globally and winning key industry awards.

With Marek’s international experience, we’re ready to take Enantis to the next level and continue pushing boundaries in biotechnology!

hashtag#LeadershipChange hashtag#Innovation hashtag#Biotechnology hashtag#Enantis hashtag#GlobalExpansion

At In-Cosmetics 2024 in Paris, we started an exciting collaboration with Sunfine Global (Juyeon Song), a Korean cosmetics and chemical ingredients company. Terézia Ikrényiová and Alzbeta Hauser are now set to present our groundbreaking anti-aging ingredient in Korea in a couple of days, aiming to attract customers in Korea and expand our market presence across the broader Asian market. Kamsahamnida (감사합니다) to Sunfine Global for this opportunity.