FGF2-STAB® – saves money and labor
We focus on the stabilization of proteins from the FGF family. FGF2-STAB (stable Fibroblast growth factor 2) is currently our top product from our protein engineering efforts. It retains full biological activity even after twenty days at 37°C (the half-life of biological activity of a wild type FGF2 is 9 hours at 37°C). FGF2 is a pleiotropic regulator of proliferation, differentiation, migration, and survival in a variety of cell types.
FGF2-STAB can be used in:
- Stem cell cultivation
FGF2 is an essential component of media for the cultivation of pluripotent stem cells because it helps maintain the cells in the pluripotent state. Improved stability makes daily changes of media useless and since less protein is needed, it makes stem cell cultivation cheaper and less labor intensive.
- Health care
Research shows that FGF2 plays an important role in wound healing, diabetic foot ulcer treatment, periodontal regeneration, bone regrowth, cancer treatment, cardioprotection, neuroprotection, and the treatment of mood disorders. Thanks to the H2020 SME Instrument phase 2 support, we are conducting a preclinical trial focused on the application of FGF2-STAB in wound healing.
FGF2 has been shown to increase skin elasticity, decrease the depth of wrinkles, increase hydration of skin, decrease the depth of pigmentation, and promote hair growth by inducing the anagen growth phase of hair follicles. Potential applications in skin care include rejuvenation of the epidermal cells and the underlying fibroblast cells, which produce collagen, elastin, and hyaluronic acid.